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CHRISTINA APPLEGATE (Voice of Britanny) stars as Reagan, a career-driven and energetic woman trying to juggle the demands of career, marriage and motherhood, on NBC's new comedy Up All Night.

Applegate has endeared herself to audiences and received accolades for her strength and versatility in theater, film and television. With Emmy, Golden Globe and Tony® nominations to her credit, she has proven herself to be one of Hollywood's most influential leading ladies.

Applegate first gained widespread attention as the sexy and sarcastic Kelly Bundy on the long-running series Married with Children. After a very successful 11-season run, she furthered her television success by starring in her own NBC comedy series, Jesse. In 1999, the highly-rated show garnered Applegate a People's Choice Award as Favorite Female Performer in a New Television Series, and a Golden Globe nomination in the category of Best Performance by an Actress in a TV Series, Comedy or Musical.

Most recently, she was seen in Nanette Burstein's romantic comedy feature, Going the Distance, with Justin Long and Drew Barrymore. Last summer, Applegate played the voice of Catherine in the animated 3-D comedy, Cats & Dogs: the Revenge of Kitty Galore.

In December 2010, she starred as Brittany, the lead Chipette, in Alvin and the Chipmunks: The Squeakquel. The film was number one at the box office and remained in the top five through January. She had previously voiced the role in Alvin and the Chipmunks. She also joined Owen Wilson, Jason Sudeikis and Jenna Fischer in Hall Pass.

Applegate's performance as the title character in the series Samantha Who?, garnered her a third SAG Award nomination in 2010. Previous nods include two Emmy nominations for Outstanding Lead Actress in a Comedy Series, two Golden Globe nominations for Best Performance by an Actress in a Television Series, a Satellite Award nomination for Best Actress in a Series, Comedy or Musical and a Prism Award nomination for Performance in a Comedy Series. In addition, Applegate served as a producer for the show, which won a People's Choice Award for Favorite New TV Comedy during its first season.

Additional film credits include The Rocker from director Peter Cattaneo, where she starred opposite Rainn Wilson; Surviving Christmas for director Mike Mitchell; the comedy Anchorman: The Legend of Ron Burgundy with Will Ferrell; the raucous comedy The Sweetest Thing, alongside Cameron Diaz and Selma Blair, which garnered Applegate critical praise; Wonderland; View from the Top with Gwyneth Paltrow; and Stephen Herek's Don't Tell Mom the Babysitter's Dead.

In 2005, Applegate made her Broadway debut in the starring role as Charity Hope Valentine in the revival of Sweet Charity, which earned Applegate a Tony Award nomination for Best Performance by a Leading Actress in a Musical as well as a Drama Desk Award in the category of Outstanding Actress in a Musical. Other stage credits include an appearance in John Cassavetes' Los Angeles production of The Third Day with Gena Rowlands, The Axeman's Jazz, Nobody Leaves Empty Handed, The Run-Through and The Grass Harp.

In 2008, after receiving her breast cancer diagnosis through an early, doctor-ordered MRI, Applegate founded Right Action for Women (RAW) to educate young women about their risk for breast cancer, while encouraging them to speak with their caregivers about appropriate screening. Additionally, RAW provides financial assistance to qualified women to cover the high costs associated with breast screenings. In 2003 and 2009, she served as the ambassador for Lee National Denim Day, one of the largest single-day fundraisers for breast cancer in the country.


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