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Clarissa "Clary" Fray(Lily Collins) -- Clary Fray is living a low-key and relatively sheltered life in bohemian Brooklyn when her mother suddenly disappears and their apartment is left in shambles. Searching for her missing mom, the beautiful and sensitive young woman is astonished to learn that she is the descendent of a long line of Shadowhunters, human-angel hybrids charged with protecting humanity from unseen evil. As she valiantly faces a shocking new world filled with demons, vampires and werewolves to track down her mom, Clary must also learn to harness the power she has suddenly discovered and to navigate an unfamiliar tangle of new friends and adversaries -- who are often difficult to tell apart.

Jace Wayland (Jamie Bower Campbell) -- An orphaned Shadowhunter raised by the Lightwood family, Jace is cocky, courageous and extremely deadly. One of the world's most ferocious and effective Shadowhunters, Jace takes Clary under his wing, introducing her to his foster siblings, Alex and Isabelle Lightwood, and their mentor, Hodge Starkweather, as she begins to put together the pieces of her family history. Angelically handsome as well as a fierce warrior, Jace finds himself drawn to Clary in a way he has never felt before, despite his friends' objection to her presence.

Simon Lewis(Robert Sheehan) -- A slightly geeky gamer with an irreverent sense of humor, Simon has been Clary's best friend since childhood. When Clary is drawn into the treacherous world of the Shadowhunters, Simon remains by her side without any thought for his own safety. He is also completely in love with Clary, a fact that is obvious to everyone but her.

Isabelle Lightwood(Jemima West) -- As slender, graceful and deadly as a dagger, Isabelle has spent her entire young life training beside Jace and Alec to hunt down the demons that threaten humankind. Accustomed to being the only female on the team, she initially resents Clary's presence, but when she sees the newcomer's innate skill and courage, Isabelle becomes her mentor and friend.

Alec Lightwood(Kevin Zegers) -- Isabelle's older brother and Jace's best friend, Alec is intense and reserved. The elder of the Lightwood siblings, he is extremely protective of his family. Alec resents Clary's intrusion on his relationship with Jace and mistrusts her motives for joining the Shadowhunters.

Hodge Starkweather (Jared Harris) -- Hodge tutors the young Shadowhunters at the New York Institute, including Jace, Isabelle, Alec -- and eventually Clary. A former member of Valentine Morgenstern's infamous Circle, Hodge has been confined within the Institute walls for the past 16 years as punishment for his transgressions, and he is desperate to find a way out.

Valentine Morgenstern(Jonathan Rhys Meyers) -- Valentine is a renegade Shadowhunter who formed a band of rebels known as the Circle and stole the Mortal Cup -- the vessel that created the Shadowhunters 1,000 years ago. Decades of experimentation with the Cup have warped Valentine to the core, making him the most powerful Shadowhunter who has ever lived, as well as the most evil. He believes that Jocelyn stole and hid the Cup and will do anything to get it back.

Jocelyn Fray (Lena Headey) -- Clary's mother, Jocelyn was once a daring Shadowhunter herself, but she fled to a quiet life in the "mundane" world, taking her daughter into hiding with her. Believing that Jocelyn knows the whereabouts of the missing Mortal Cup, Valentine dispatches his henchmen to abduct her so that Clary will help him locate it.

Luke Garroway (Aidan Turner) -- Luke is Jocelyn's confidante and the closest thing to a father Clary has known. By day, he runs a SoHo antique store, but by night, Luke is the leader of New York City's powerful werewolf pack. A Shadowhunter and member of the Circle, he is devoted to the Fray women and marshals the strength of his pack when he learns that Clary and Jocelyn are in danger.

Magnus Bane(Godfrey Gao) -- The 800-year-old High Warlock of Brooklyn, Magnus appears to be in his early 20s, with an intense personal magnetism and flamboyant style that make him irresistible to both men and women. Unbeknownst to Clary, her mother has been depending on Magnus' magic to protect the girl for many years.

Madame Dorothea (CCH Pounder) -- Clary and Jocelyn's downstairs neighbor, Madame Dorothea is a real-life witch masquerading as a store-front psychic in the "mundane" world. Although she is unaware of it, she is hiding the key to an important mystery on Jocelyn's behalf.

Emile Pangborn and Samuel Blackwell (Kevin Durand and Robert Maillet) -- Valentine's enforcers, Pangborn and Blackwell take Jocelyn hostage in an effort to locate the Mortal Cup for their boss. Massive and ruthless, they are also deeply loyal to Valentine and his cause.

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